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Plasmid carriage and the unorthodox use of Fisher's theorem in evolutionary biology

The link between fitness and reproduction rate is a central tenet in evolutionary biology: mutants reproducing faster than the dominant wild-type are favoured by selection, otherwise the mutation is lost. This link is given by Fisher's theorem under …

Canonical host-pathogen tradeoffs subverted by mutations with dual benefits

Tradeoffs between life history traits impact diverse biological phenomena, including the maintenance of biodiversity. We sought to study two canonical tradeoffs in a model host-parasite system consisting of bacteriophage lambda and _Escherichia …

Fluorescence photography of patterns and waves of bacterial adaptation at high antibiotic doses

Fisher suggested advantageous genes would spread through populations as a wave so we sought genetic waves in evolving populations, as follows. By fusing a fluorescent marker to a drug efflux protein (AcrB) whose expression provides _Escherichia coli_ …